Benzaldehyde, 4-(phenylmethoxy)- → HCID 69504435, compound

HRID 1268951Notes

Reaction equation

HRID 1268951 reaction equation
[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:27])[CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[CH:19][CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O-]S(C(F)(F)F)(=O)=O.C([B+]CCCC)CCC.[CH2:45]([O:52][C:53]1[CH:60]=[CH:59][C:56]([CH:57]=[O:58])=[CH:55][CH:54]=1)[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1>ClCCl.C(N(CC)CC)C>[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:27])[C@@H:15]([O:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([CH3:24])([CH3:26])[CH3:25])=[CH:19][CH:18]=1)[C@@H:57]([C:56]1[CH:59]=[CH:60][C:53]([O:52][CH2:45][C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)=[CH:54][CH:55]=1)[OH:58])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 78109Benzaldehyde, 4-(phenylmethoxy)-HCID 69504518HCID 69504518, compoundHCID 178418657HCID 178418657, compound

Product 1

HCID 69504435HCID 69504435, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8471TriethylamineSolvent

Procedure

The target compound (30.0 g) was obtained as a colorless oil by carrying out the reaction and the post-treatment according to Reference example 20(b) using (S)-4-benzyl-3-[(4-t-butylphenoxy)acetyl]oxazolidin-2-one (28.2 g) obtained from Reference example 21(a), a solution of dibutylboron triflate in dichloromethane (1M, 92.1 ml), triethylamine (13.9 ml) and 4-benzyloxybenzaldehyde (17.9 g).

Workup

  1. customthe reaction

Sources & evidence

ORD record
ord-d8533fcc1206439889aee57d971a9500
Source dataset
uspto-grants-2007_04
Patent number
US07199139B2

Reaction notes

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