Benzaldehyde, 4-(phenylmethoxy)- → HCID 69504523, compound

HRID 1268955Notes

Reaction equation

HRID 1268955 reaction equation
[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:24])[CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O-]S(C(F)(F)F)(=O)=O.C([B+]CCCC)CCC.[CH2:42]([O:49][C:50]1[CH:57]=[CH:56][C:53]([CH:54]=[O:55])=[CH:52][CH:51]=1)[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1>ClCCl.C(N(CC)CC)C>[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:24])[C@@H:15]([O:16][C:17]1[CH:18]=[CH:19][C:20]([F:23])=[CH:21][CH:22]=1)[C@@H:54]([C:53]1[CH:56]=[CH:57][C:50]([O:49][CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)=[CH:51][CH:52]=1)[OH:55])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 78109Benzaldehyde, 4-(phenylmethoxy)-HCID 69504410HCID 69504410, compoundHCID 178418657HCID 178418657, compound

Product 1

HCID 69504523HCID 69504523, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8471TriethylamineSolvent

Procedure

The target compound (2.68 g) was obtained as a foam by carrying out the reaction and the post-treatment according to Reference example 20(b) using (S)-4-benzyl-3-[(4-fluorophenoxy)acetyl]oxazolidin-2-one (1.96 g) obtained from Reference example 22(a), a solution of dibutylboron triflate in dichloromethane (1M, 7.14 ml), triethylamine (1.08 ml) and 4-benzyloxybenzaldehyde (1.39 g).

Workup

  1. customthe reaction

Sources & evidence

ORD record
ord-51ca32bcac364123aeb637e7e8d72dd1
Source dataset
uspto-grants-2007_04
Patent number
US07199139B2

Reaction notes

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