2-(Trimethylsilyl)ethanol → HCID 131726318, compound

HRID 1268958Notes

Reaction equation

HRID 1268958 reaction equation
[F:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][C@@H:7]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.C(Cl)(=O)C(Cl)=O.[CH3:27][Si:28]([CH3:33])([CH3:32])[CH2:29][CH2:30]O>>[F:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][C@@H:7]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[C:8]([O:10][CH2:30][CH2:29][Si:28]([CH3:33])([CH3:32])[CH3:27])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 180132-(Trimethylsilyl)ethanolHCID 65578Oxalyl chlorideHCID 69504442HCID 69504442, compound

Product 1

HCID 131726318HCID 131726318, compound

Procedure

The target compound (1.81 g) was obtained as colorless crystals by carrying out the reaction and the post-treatment according to Reference example 20(e) using the above carboxylic acid (2.30 g), oxalyl chloride (1.80 ml) and 2-trimethylsilylethanol (15.96 ml).

Workup

  1. customthe reaction

Sources & evidence

ORD record
ord-0c854cccb8f944debb5ff6ffb0f4e405
Source dataset
uspto-grants-2007_04
Patent number
US07199139B2

Reaction notes

Loading…