Potassium Carbonate → HCID 54189168, compound

HRID 1268964Notes

Reaction equation

HRID 1268964 reaction equation
Br[CH2:2][CH2:3][O:4]C1CCCCO1.[F:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24](=[N:26][OH:27])[CH3:25])=[CH:20][CH:19]=2)=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[F:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24](=[N:26][O:27][CH2:2][CH2:3][OH:4])[CH3:25])=[CH:20][CH:19]=2)=[CH:16][CH:17]=1

Participants

5

Reactant 4

HCID 11430Potassium CarbonateHCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 521998p-Toluenesulfonic acid monohydrateHCID 85980690HCID 85980690, compound

Product 1

HCID 54189168HCID 54189168, compound

Procedure

The target compound (3.84 g) was obtained as white crystals by carrying out the reaction and the post-treatment according to Reference examples 1(c) and 1(d) of WO 97/37970(EP 916651A) using 2-(2-bromoethoxy)tetrahydropyran (6.84 g), 4′-(4-fluorophenyl)acetophenone oxime (5.00 g), potassium carbonate (6.02 g) and a catalytic amount of p-toluenesulfonic acid monohydrate.

Workup

  1. customthe reaction

Sources & evidence

ORD record
ord-2b3d993f7d43496f825070b428ab7400
Source dataset
uspto-grants-2007_04
Patent number
US07199139B2

Reaction notes

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