Trifluoroacetic acid → HCID 18448579, compound

HRID 1269454Notes

Reaction equation

HRID 1269454 reaction equation
C(OC([N:8]1[CH2:12][CH:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH:9]1[CH2:21][C:22](=[O:36])[NH:23][CH:24]1[C:33]2[C:28](=[CH:29][C:30]([CH2:34][OH:35])=[CH:31][CH:32]=2)[CH2:27][CH2:26][CH2:25]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:14]([O:13][CH:11]1[CH2:12][NH:8][CH:9]([CH2:21][C:22]([NH:23][CH:24]2[C:33]3[C:28](=[CH:29][C:30]([CH2:34][OH:35])=[CH:31][CH:32]=3)[CH2:27][CH2:26][CH2:25]2)=[O:36])[CH2:10]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69427203HCID 69427203, compound

Product 1

HCID 18448579HCID 18448579, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Benzyloxy-2-[(6-hydroxymethyl-1,2,3,4-tetrahydro-naphthalen-1-ylcarbamoyl)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (480 mg. 97 mmol) was dissolved in 25 mL CH2Cl2 and treated with 10 mL TFA and stirred at RT for 15 min, then concentrated to afford the title compound as a colorless glass. (MS,395, M+H).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-6ec1d6ce194d496eb6224180ac0d66ca
Source dataset
uspto-grants-2007_04
Patent number
US07199244B2

Reaction notes

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