反应详情

温度

100 °C

A mixture of of allylamine (0.447 mL, 5.96 mmol) and 2-bromo-6-[4-(trifluoromethyl)phenyl]pyridine (0.1 g, 0.298 mmol) in ethanol (5 mL) were heated at 100° C. in a 25 mL pressure vessel. After heating overnight the reaction was cooled and copper sulfate was added and heating continued at 100° C. overnight. After this time the reaction was allowed to coole to room temperature and concentrated in vacuo. Purification by SPE (Silica, 10 g) eluting 3:1 cyclohexane:chloroform afforded the title compound as a dark yellow solid (0.062 g).

1. temperatureAfter heating overnight the reaction
2. temperaturewas cooled
3. temperatureheating
4. customto coole to room temperature
5. concentrationconcentrated in vacuo
6. customPurification by SPE (Silica, 10 g)
7. washeluting 3:1 cyclohexane