HCID 9836178, compound → HCID 9908775, compound

HRID 1269714Notes

Reaction equation

HRID 1269714 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[NH:20][N:19]=[CH:18]3)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:24].CC[O:27]CC>O1CCCC1>[OH2:27].[ClH:24].[ClH:24].[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[NH:20][N:19]=[CH:18]3)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9836178HCID 9836178, compoundHCID 10953452Ether hydrochloride

Product 1

HCID 9908775HCID 9908775, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of N-(1-benzyl-4-piperidinyl)-1H-indazol-5-amine (3.06 g, 10.0 mmol) in tetrahydrofuran (31 ml) was added a 1N-hydrochloric acid/ether solution (25 ml) at room temperature, and stirred at room temperature for 30 minutes. The solid precipitated was collected by filtration and recrystallized from methanol to obtain N-(1-benzyl-4-piperidinyl)-1H-indazol-5-amine dihydrochloride monohydrate (2.86 g, 72%).

Workup

  1. customThe solid precipitated
  2. filtrationwas collected by filtration
  3. customrecrystallized from methanol

Sources & evidence

ORD record
ord-844181bed9764968b2ab81609e53d5d2
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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