Hydrogen Bromide → HCID 69415746, compound

HRID 1270165Notes

Reaction equation

HRID 1270165 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]1[C:15]([O:18]C)=[N:16][N:17]=[C:10]1[C:9]([NH:20][CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=1)=[N:8]2)=[O:4].Br>CC(O)=O>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]1[C:15](=[O:18])[NH:16][N:17]=[C:10]1[C:9]([NH:20][CH2:21][CH2:22][C:23]1[CH:24]=[CH:25][N:26]=[CH:27][CH:28]=1)=[N:8]2)=[O:4]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 69415327HCID 69415327, compound

Product 1

HCID 69415746HCID 69415746, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 1-methoxy-4-(2-pyridin-4-ylethylamino)-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid methyl ester (32 mg) was treated with 48% HBr (4 mL) in AcOH (6 mL) at 23° C. After 2 hrs., the solution was concentrated. Trituration of the residue with MeOH/methylene chloride, followed by filtration, afforded a light yellow solid. MS (M+H)+=365.3.

Workup

  1. concentration, the solution was concentrated
  2. filtrationTrituration of the residue with MeOH/methylene chloride, followed by filtration
  3. customafforded a light yellow solid

Sources & evidence

ORD record
ord-d915857e429f4379bf651c42e7ee55d8
Source dataset
uspto-grants-2007_04
Patent number
US07202245B2

Reaction notes

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