HCID 18449248, compound → HCID 18449204, compound

HRID 1270169Notes

Reaction equation

HRID 1270169 reaction equation
[CH:1]([NH:4][C:5]1[C:6]2[N:7]([C:23]([O:26]C)=[N:24][N:25]=2)[C:8]2[C:13]([N:14]=1)=[CH:12][C:11]([CH2:15][N:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1)=[CH:10][CH:9]=2)([CH3:3])[CH3:2]>CC(O)=O.Br>[CH:1]([NH:4][C:5]1[C:6]2[N:7]([C:23](=[O:26])[NH:24][N:25]=2)[C:8]2[C:13]([N:14]=1)=[CH:12][C:11]([CH2:15][N:16]1[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]1)=[CH:10][CH:9]=2)([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 18449248HCID 18449248, compound

Product 1

HCID 18449204HCID 18449204, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Conditions

Temperature
90 °C

Procedure

A solution of isopropyl-[1-methoxy-7-(4-methyl-piperazin-1-ylmethyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl]amine (12 mg) in AcOH (1 mL) and 48% HBr (0.5 mL) was stirred at 23° C. for 90 min., then was heated to 90° C. for 100 min. After cooling to 23° C., the solution was concentrated. The resulting residue was concentrated from toluene. Trituration of the residue with MeOH/EtOAc afforded the title compound as a light yellow solid. MS (M+H)+=356.4.

Workup

  1. temperatureAfter cooling to 23° C.
  2. concentrationthe solution was concentrated
  3. concentrationThe resulting residue was concentrated from toluene

Sources & evidence

ORD record
ord-24eb77a2d14f4807964e950312730f5a
Source dataset
uspto-grants-2007_04
Patent number
US07202245B2

Reaction notes

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