反应详情

温度

0 °C

To an ice-cold mixture of the product from Step A (475 mg, 0.7 mmol) in THF (7 mL) was added NaH (60% in mineral oil, 29 mg) and stirred at 0° C. for 0.5 h. Then MeI (48 μL) was added and reaction mixture stirred at rt for 24 h. The reaction was quenched with MeOH and the mixture evaporated. The crude product was purified on a silica gel column (5×3.5 cm) using hexane/ethyl acetate (9/1, 7/1, 5/1 and 3/1) as eluent. Fractions containing the product were combined and evaporated to give the desired compound (200 mg) as a colorless foam.

1. customreaction mixture
2. stirringstirred at rt for 24 h
3. customThe reaction was quenched with MeOH
4. customthe mixture evaporated
5. customThe crude product was purified on a silica gel column (5×3.5 cm)
6. additionFractions containing the product
7. customevaporated