反应详情

4-Bromobenzonitrile (36.4 g, 0.2 mol), ammonium bromide (39.2 g, 0.4 mol) and ammonia gas (34.0 g, 2 mol) are heated under autogenous pressure in an autoclave for 9 h at 140–150° C. The autoclave contents are concentrated and extracted by stirring with ethanol. The residue is filtered off and again extracted by stirring with ethanol. The extracts are combined and concentrated to about 100 ml. The precipitated solid is filtered off with suction, washed with ethanol and dried.

1. concentrationThe autoclave contents are concentrated
2. extractionextracted
3. filtrationThe residue is filtered off
4. extractionagain extracted
5. stirringby stirring with ethanol
6. concentrationconcentrated to about 100 ml
7. filtrationThe precipitated solid is filtered off with suction
8. washwashed with ethanol
9. customdried