反应详情

温度

90 °C

To a solution of 350 mg (1.04 mmol) of 5,7-dimethyl-2-(3-nitrophenyl)-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]triazine from example 12A in DMF is treated with 290 mg (1.56 mmol) of 3,4,5-trimethoxyaniline and 220 mg (1.56 mmol) of potassium carbonate. The reaction mixture is stirred overnight at 90° C. After cooling, the solvent is removed on a rotary evaporator, the residue is treated twice more with toluene and the solvent is removed in vacuo. The product is extracted by stirring with a little methanol and filtered off with suction.

1. temperatureAfter cooling
2. customthe solvent is removed on a rotary evaporator
3. additionthe residue is treated twice more with toluene
4. customthe solvent is removed in vacuo
5. extractionThe product is extracted
6. stirringby stirring with a little methanol
7. filtrationfiltered off with suction