1,2-Dichloroethane → N-(4-{5,7-Dimethyl-4-[(3,4,5-trimethoxyphenyl)amino]imidazo[5,1-f][1,2,4]triazin-2-yl}phenyl)propanamide

HRID 1270322Notes

Reaction equation

HRID 1270322 reaction equation
[C:1]([OH:5])(=O)[CH2:2][CH3:3].C1C=CC2N(O)N=NC=2C=1.CN1CCOCC1.C(Cl)CCl.[NH2:27][C:28]1[CH:33]=[CH:32][C:31]([C:34]2[N:39]=[C:38]([NH:40][C:41]3[CH:46]=[C:45]([O:47][CH3:48])[C:44]([O:49][CH3:50])=[C:43]([O:51][CH3:52])[CH:42]=3)[C:37]3=[C:53]([CH3:57])[N:54]=[C:55]([CH3:56])[N:36]3[N:35]=2)=[CH:30][CH:29]=1>>[CH3:57][C:53]1[N:54]=[C:55]([CH3:56])[N:36]2[C:37]=1[C:38]([NH:40][C:41]1[CH:42]=[C:43]([O:51][CH3:52])[C:44]([O:49][CH3:50])=[C:45]([O:47][CH3:48])[CH:46]=1)=[N:39][C:34]([C:31]1[CH:30]=[CH:29][C:28]([NH:27][C:1](=[O:5])[CH2:2][CH3:3])=[CH:33][CH:32]=1)=[N:35]2

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 1032Propionic AcidHCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 11742877N-[2-(4-Aminophenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4-yl]-N-(3,4,5-trimethoxyphenyl)amine

Product 1

HCID 10344915N-(4-{5,7-Dimethyl-4-[(3,4,5-trimethoxyphenyl)amino]imidazo[5,1-f][1,2,4]triazin-2-yl}phenyl)propanamide

Procedure

13 mg (0.17 mmol) of propionic acid, 23 mg (0.17 mmol) of HOBt, 47 mg (0.46 mmol) of 4-methylmorpholine, 33 mg (0.17 mmol) of EDC and 65 mg (0.21 mmol) of N-[2-(4-aminophenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4-yl]-N-(3,4,5-trimethoxyphenyl)amine from example 3 are reacted analogously to example 2.

Sources & evidence

ORD record
ord-8a9d576a71dd4dea9a28ade2ce38068f
Source dataset
uspto-grants-2007_04
Patent number
US07202243B2

Reaction notes

Loading…