Hydrochloric Acid → HCID 11709089, compound

HRID 1270607Notes

Reaction equation

HRID 1270607 reaction equation
[C:1]([O:6][CH2:7][C:8]([CH3:20])([OH:19])[C:9]([F:18])([F:17])[C:10](O)([OH:15])[C:11]([F:14])([F:13])[F:12])(=[O:5])[C:2]([CH3:4])=[CH2:3].Cl>C(Cl)Cl>[C:1]([O:6][CH2:7][C:8]([OH:19])([CH3:20])[C:9]([F:17])([F:18])[CH:10]([OH:15])[C:11]([F:14])([F:13])[F:12])(=[O:5])[C:2]([CH3:4])=[CH2:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11515081HCID 11515081, compound

Product 1

HCID 11709089HCID 11709089, compoundYield 91.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 30.8 g of 2-methyl-3,3,5,5,5-pentafluoro-2,4,4-trihydroxypentyl methacrylate obtained in Example 1 and 300 g of methylene chloride was added 8.7 g of borane-t-butylamine complex, followed by 24 hours of stirring. Dilute hydrochloric acid was added to stop the reaction. Through conventional aqueous work-up and purification by silica gel column chromatography, 26.6 g of the target compound was obtained (yield 91%).

Workup

  1. additionwas added 8.7 g of borane-t-butylamine complex
  2. customthe reaction
  3. customThrough conventional aqueous work-up and purification by silica gel column chromatography

Sources & evidence

ORD record
ord-9b2564298be64d77853f51ceb859643d
Source dataset
uspto-grants-2007_04
Patent number
US07202318B2

Reaction notes

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