反应详情

温度

140 °C

A mixture of 2.52 g (10 mmoles) of 3-trimethylsilyloxy-4-p-fluorophenoxy-1-butyne (Example 158), 2.91 g (10 mmoles) of tri-n-butyl-tin hydride, and 10 mg of azobisisobutyronitrile is heated, under an argon atmosphere, with stirring, for 2 hours at 140° C. After cooling to room temperature, the crude reaction mixture is fractionally distilled at 180°-185° C. (0.05 mm), to give 4.6 g (85%) of the subject product as a colorless liquid.

1. temperatureis heated, under an argon atmosphere
2. temperatureAfter cooling to room temperature
3. customthe crude reaction mixture
4. distillationis fractionally distilled at 180°-185° C. (0.05 mm)