Benzenesulfonamide → Benzenesulfonanilide

HRID 1270702Notes

Reaction equation

HRID 1270702 reaction equation
[C:1]1([S:7]([NH2:10])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.I[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[C:12]1([NH:10][S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:9])=[O:8])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 7370BenzenesulfonamideHCID 10796Cesium carbonateHCID 11575Iodobenzene

Product 1

HCID 74296Benzenesulfonanilide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Example 2.1 was repeated, using 14.4 mg of cuprous oxide (0.1 mmoles), 117 mg of Chxn-Py-Al (0.4 mmoles), 472 mg of benzenesulphonamide (3 mmoles), 224 μl of iodobenzene (2 mmoles), 1.04 g of caesium carbonate (3.2 mmoles), 600 mg of ground and activated 3 Å molecular sieve and 1.6 ml of DMF.

Sources & evidence

ORD record
ord-b1e2e46933cb42b2a42052ce7504a243
Source dataset
uspto-grants-2007_04
Patent number
US07202367B2

Reaction notes

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