Diethyl Malonate → Diethyl phenylmalonate

HRID 1270708Notes

Reaction equation

HRID 1270708 reaction equation
[C:1]([O:9][CH2:10][CH3:11])(=[O:8])[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].I[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(#N)C>[C:13]1([CH:2]([C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:1]([O:9][CH2:10][CH3:11])=[O:8])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 7761Diethyl MalonateHCID 11575Iodobenzene

Product 1

HCID 66514Diethyl phenylmalonate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

607 μl of diethyl malonate (3 mmoles), 224 μl of iodobenzene (2 mmoles), 1.2 ml of acetonitrile and 600 mg of ground and activated 3 Å molecular sieve were then added.

Workup

  1. additionwere then added

Sources & evidence

ORD record
ord-9a371363651944a39408bdca0014876c
Source dataset
uspto-grants-2007_04
Patent number
US07202367B2

Reaction notes

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