反应详情

温度

40 °C

N,N-dimethyl-2-iodophenylacetamide (2.0 g, 6.9 mmol), 2,3,5,6-tetrafluoro-4-phenylaniline (3.3 g, 13.8 mmol), copper powder (219 mg, 3.4 mmol), copper(I) iodide (646 mg, 3.4 mmol) and anhydrous potassium carbonate (1.0 g, 6.9 mmol) are stirred together in 150 mL of xylenes. The reaction is heated to reflux temperature for 48 hours. While still slightly warm (40° C.) the brown suspension is filtered through a pad of Celite which in turn is rinsed with toluene (250 mL). The filtrate is evaporated by rotary evaporator and then flash chromatographed on silica gel (10–20% EtOAc/hexane) to give the title product.

1. temperatureThe reaction is heated
2. temperatureto reflux temperature for 48 hours
3. filtrationis filtered through a pad of Celite which in turn
4. washis rinsed with toluene (250 mL)
5. customThe filtrate is evaporated by rotary evaporator
6. customflash chromatographed on silica gel (10–20% EtOAc/hexane)