反应详情

N2-[4-(4-amino-7-cyanothieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl]-1-methyl-1H-2-indolecarboxamide (A-825289.0, 50 mg, 0.11 mmol), potassium carbonate (61 mg, 0.44 mmol), and hydrogen peroxide (0.150 mL, 30% aqueous) were heated in dimethylsulfoxide (1 mL) for 25 minutes at 150° C. in a microwave. The mixture was evaporated, diluted in dimethylformamide, filtered, and the filtrate was purified by RP-HPLC to yield the title compound (2 mg, 4% yield): 1H NMR (DMSO-d6, 400 MHz) δ 9.50 (s, 1H), 8.57 (s, 1H), 8.00 (d, 1H), 7.71 (d, 1H), 7.58–7.62 (m, H), 7.06–7.35 (m, 5H), 4.04 (s, 3H); RP-HPLC (Conditions i) Rt 11.7 min. MS: 470.0 MH−.

1. customThe mixture was evaporated
2. additiondiluted in dimethylformamide
3. filtrationfiltered
4. customthe filtrate was purified by RP-HPLC