反应详情

10.00 g of 3-(dimethylamino)-1,2-diphenyl-2-propen-1-one, 6.90 g of 1-methylguanidine hydrochloride and 8.70 g of potassium carbonate were added to 20 ml of xylene and then heated at reflux for 13 hours using a reflux condenser equipped with a Dean-Stark water separator. The reaction solution was extracted with ethyl acetate after adding water, dried over anhydrous magnesium sulfate, and then the solvent was evaporated. The crude crystal was washed with diisopropyl ether and dried to obtain 6.51 g of the desired compound as a pale yellow crystal having a melting point of 136 to 138° C.

1. temperatureheated
2. temperatureat reflux for 13 hours
3. extractionThe reaction solution was extracted with ethyl acetate
4. additionafter adding water
5. dry with materialdried over anhydrous magnesium sulfate
6. customthe solvent was evaporated
7. washThe crude crystal was washed with diisopropyl ether
8. customdried