反应详情

A suspension of 1-chloromethyl-4-nitro-benzene (10 g, 58.3 mmol) and sodium iodide in acetone (150 ml) was refluxed for 1 h. Water was added until complete dissolution and the mixture extracted with ethyl acetate (4×100 ml). The combined organic layers were extracted with brine, dried over sodium sulfate and concentrated in vacuo yielding 13.9 g (95%) 1-Iodomethyl-4-nitro-benzene as beige crystals.

1. temperaturewas refluxed for 1 h
2. extractionthe mixture extracted with ethyl acetate (4×100 ml)
3. extractionThe combined organic layers were extracted with brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated in vacuo