反应详情

2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-oxazole-4-carboxylic acid (100 mg, 0.35 mmol), N-ethyl-N′-(3-dimethyl-aminopropyl)carbodiimide hydrochloride (101 mg, 0.53 mmol), 1-Hydroxybenzotriazole hydrate (73 mg, 0.53 mmol) and triethylamine (71 mg, 0.71 mmol) are suspended in dichloromethane (5 ml). After stirring at room temperature for 15 min 4-(4-[1,2,3]Triazol-1-yl-butyl)-phenylamine (84 mg, 0.39 mmol) is added and stirring is continued for 20 h. Ethyl acetate (10 ml) is added and the mixture washed with aq. HCl (1N, 10 ml), sat. NaHCO3, (10 ml), dried over sodium sulfate and concentrated in vacuo. The crude product is purified by flash column chromatography (ethyl acetate/heptane 9:1) yielding 2-[2-(4-trifluoromethyl-phenyl)-vinyl]-oxazole-4-carboxylic acid [4-(4-[1,2,3]triazol-1-yl-butyl)-phenyl]-amide 11 as a colorless solid. Yield 109 mg (64%); m.p. 183–185° C.

1. additionis added
2. washthe mixture washed with aq. HCl (1N, 10 ml), sat. NaHCO3, (10 ml)
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated in vacuo
5. customThe crude product is purified by flash column chromatography (ethyl acetate/heptane 9:1)