Hydrochloric Acid → HCID 68588477, compound

HRID 1271511Notes

Reaction equation

HRID 1271511 reaction equation
C[O:2][C:3]([C:5]1[C:6]([S:15][C@H:16]2[CH2:25][CH2:24][C@@H:23]3[C@@H:18]([CH2:19][C@@H:20]([C:30]([O:32]CC)=[O:31])[N:21](C(OC)=O)[CH2:22]3)[CH2:17]2)=[CH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:4].[ClH:35]>>[ClH:35].[C:3]([C:5]1[C:6]([S:15][C@H:16]2[CH2:25][CH2:24][C@@H:23]3[C@@H:18]([CH2:19][C@@H:20]([C:30]([OH:32])=[O:31])[NH:21][CH2:22]3)[CH2:17]2)=[CH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)([OH:4])=[O:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86640932HCID 86640932, compound

Product 1

HCID 68588477HCID 68588477, compoundYield 96%

Procedure

The alkylated decahydroisoquinoline derivative from step C (36 mg, 0.075 mmol) was treated with 6M hydrochloric acid under reflux for 35 h. The solution was concentrated in vacuo and water added and concentrated in vacuo (3×), followed by addition of acetone and concentration in vacuo (3×), to give an off-white solid (30 mg, 96% yield).

Workup

  1. temperatureunder reflux for 35 h
  2. concentrationThe solution was concentrated in vacuo and water
  3. additionadded
  4. concentrationconcentrated in vacuo (3×)
  5. additionfollowed by addition of acetone and concentration in vacuo (3×)

Sources & evidence

ORD record
ord-dc6d1ae3aa2043a097571158ec2b032c
Source dataset
uspto-grants-2007_04
Patent number
US07205313B2

Reaction notes

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