Hydrochloric Acid → HCID 18454779, compound

HRID 1271556Notes

Reaction equation

HRID 1271556 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]#[C:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:5]([NH2:16])=[CH:4][CH:3]=1.[ClH:17]>C(Cl)(Cl)Cl.C(OCC)C>[ClH:17].[CH3:1][C:2]1[N:7]=[C:6]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:5]([NH2:16])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10081793HCID 10081793, compound

Product 1

HCID 18454779HCID 18454779, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent

Procedure

(6-methyl-2-phenylethynyl-pyridin-3-yl)amine (105 mg, 0.50 mmol) was dissolved in CHCl3 (2 ml) and treated with 1.56 ml (1.25 mmol) of 0.8 M hydrochloric acid solution in diethyl ether. After evaporation of the solvent and trituration of the residue with ethyl acetate, 107 mg (0.44 mmol, 87%) of the title hydrochloride were obtained as a yellowish solid.

Workup

  1. customAfter evaporation of the solvent and trituration of the residue with ethyl acetate

Sources & evidence

ORD record
ord-81fb50125565486d91e280e989b972fc
Source dataset
uspto-grants-2007_04
Patent number
US07205411B2

Reaction notes

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