1-Hydroxybenzotriazole → HCID 178456457, compound

HRID 1271606Notes

Reaction equation

HRID 1271606 reaction equation
[CH2:1]([N:4]1[C:13](=[O:14])[C:12]2[NH:11][C:10]([C:15]3[O:19][N:18]=[C:17]([O:20][CH2:21][C:22](O)=[O:23])[CH:16]=3)=[N:9][C:8]=2[N:7]([CH2:25][CH2:26][CH3:27])[C:5]1=[O:6])[CH2:2][CH3:3].[CH2:28]1[O:37][C:36]2[CH:35]=[CH:34][C:32]([NH2:33])=[CH:31][C:30]=2[O:29]1.CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1>CN(C)C=O>[CH3:27][CH2:26][CH2:25][N:7]1[C:5](=[O:6])[N:4]([CH2:1][CH2:2][CH3:3])[C:13](=[O:14])[C:12]2[C:8]1=[N:9]/[C:10](/[N:11]=2)=[C:15]1/[CH:16]=[C:17]([O:20][CH2:21][C:22]([NH:33][C:32]2[CH:34]=[CH:35][C:36]3[O:37][CH2:28][O:29][C:30]=3[CH:31]=2)=[O:23])[NH:18][O:19]/1

Participants

6

Reactant 4

HCID 757711-HydroxybenzotriazoleHCID 843101,3-Benzodioxol-5-amineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 135610070HCID 135610070, compound

Product 1

HCID 178456457HCID 178456457, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Condensation of 2-[5-(1,3-dipropyl-xanthin-8-yl)-isoxazol-3-yl)oxyacetic acid (0.5 mmol) and 3,4-methylenedioxyaniline (1.3 mmol) in the presence of EDCl (1.12 mmol) and HOBt (1.14 mmol) in anhydrous dimethylformamide afforded the desired product.

Sources & evidence

ORD record
ord-b7f527d5963941f895f305ff522737e9
Source dataset
uspto-grants-2007_04
Patent number
US07205403B2

Reaction notes

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