Triethylamine → HCID 68441993, compound

HRID 1271688Notes

Reaction equation

HRID 1271688 reaction equation
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7](Cl)=[N:6][CH:5]=1.C(N(CC)CC)C.[CH3:22][O:23][C:24](=[O:27])[CH2:25][SH:26]>ClCCl>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([S:26][CH2:25][C:24]([O:23][CH3:22])=[O:27])=[N:6][CH:5]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 16907Methyl ThioglycolateHCID 346961Methyl 6-chloro-5-nitronicotinate

Product 1

HCID 68441993HCID 68441993, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 6-chloro-5-nitro-nicotinic acid methyl ester (1.0 g) [prepared as described by A. H. Berrie et al. J. Chem. Soc. 2590–2594 (1951)] in dichloromethane (10 ml) containing triethylamine (0.76 ml) was treated with mercapto-acetic acid methyl ester (0.441 ml) and the solution was stirred at room temperature for 1 hour and evaporated to dryness. Sodium bicarbonate solution was added and the mixture was extracted with dichloromethane, dried (anhydrous sodium sulfate) and evaporated to afford a solid (1.0 g).

Workup

  1. customevaporated to dryness
  2. additionSodium bicarbonate solution was added
  3. extractionthe mixture was extracted with dichloromethane
  4. dry with materialdried (anhydrous sodium sulfate)
  5. customevaporated

Sources & evidence

ORD record
ord-f6c878856f18449391bdc47b16b1e090
Source dataset
uspto-grants-2007_04
Patent number
US07205408B2

Reaction notes

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