反应详情

4-Chloro-2-fluoro-5-methylaniline (5 g, 31.4 mmol) was dissolved in tetrahydrofuran (100 ml) and potassium carbonate (6.0 g, 37.7 mmol) and phenyl chloroformate (5.9 g, 37.7 mmol) were added. Solution was refluxed for 3 hr and the solvent was removed under reduced pressure. Product was purified by column chromatography on silica gel (eluent, methylene chloride:hexane, 6:4; 7.15 g).

1. temperatureSolution was refluxed for 3 hr
2. customthe solvent was removed under reduced pressure
3. customProduct was purified by column chromatography on silica gel (eluent, methylene chloride:hexane, 6:4; 7.15 g)