反应详情

Methanesulfonyl chloride (5.4 mmol) was added to a methylene chloride (0.2 M) solution of 5-(2-hydroxyethyl)-4-methyl-thiazole (4.5 mmol) and triethylamine (23 mmol), and stirred at room temperature overnight. The mixture was poured into water and extracted with methylene chloride. The organic extracts were washed with NaHCO3 (sat), and the product was extracted with 1M aq. HCl. The aqueous extracts were neutralized with NaHCO3 (sat) and then extracted with methylene chloride. The organic extracts were dried (MgSO4) and filtered. Solvent removal afforded product (5).

1. extractionextracted with methylene chloride
2. washThe organic extracts were washed with NaHCO3 (sat)
3. extractionthe product was extracted with 1M aq. HCl
4. extractionextracted with methylene chloride
5. dry with materialThe organic extracts were dried (MgSO4)
6. filtrationfiltered
7. customSolvent removal