Trifluoroacetic acid → HCID 9982011, compound

HRID 1271882Notes

Reaction equation

HRID 1271882 reaction equation
[NH2:1][C:2]([CH3:33])([CH3:32])[CH2:3][N:4]([CH:9]([C:13]1[N:22]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:21](=[O:30])[C:20]2[C:15](=[CH:16][C:17]([Cl:31])=[CH:18][CH:19]=2)[N:14]=1)[CH:10]([CH3:12])[CH3:11])[C:5](=[O:8])[CH:6]=[CH2:7].C(OC(=O)NC(C)(C)C(C(=O)C=C)(C(C1N(CC2C=CC=CC=2)C(=O)C2C(=CC(Cl)=CC=2)N=1)C(C)C)N)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:23]([N:22]1[C:21](=[O:30])[C:20]2[C:15](=[CH:16][C:17]([Cl:31])=[CH:18][CH:19]=2)[N:14]=[C:13]1[CH:9]([N:4]1[C:5](=[O:8])[CH2:6][CH2:7][NH:1][C:2]([CH3:32])([CH3:33])[CH2:3]1)[CH:10]([CH3:12])[CH3:11])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 18455031HCID 18455031, compoundHCID 86760486HCID 86760486, compound

Product 1

HCID 9982011HCID 9982011, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-(2-Amino-2-methyl-propyl)—N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl propyl]-acrylamide: According to the procedure of Example 1d above, ({acryloyl-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propyl]-amino-1,1-dimethyl-ethyl)-carbamic acid tert-butyl ester (730 mg, 1.29 mmol) was treated with 50% TFA in CH2Cl2 (10 mL) to give the title compound: MS (ES) m/e 467.2 (M+H)+.

Sources & evidence

ORD record
ord-eabc5066b65a45588178b054d89d3f9c
Source dataset
uspto-grants-2007_04
Patent number
US07208487B2

Reaction notes

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