Trifluoroacetic acid → HCID 86596345, compound

HRID 1272105Notes

Reaction equation

HRID 1272105 reaction equation
C(OC([N:8]1[CH2:20][C@@H:19]([CH3:21])[N:18]2[C@H:10]([CH2:11][C:12]3[C:17]2=[N:16][C:15]([Cl:22])=[C:14]([CH3:23])[CH:13]=3)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:22][C:15]1[N:16]=[C:17]2[C:12](=[CH:13][C:14]=1[CH3:23])[CH2:11][C@H:10]1[N:18]2[C@H:19]([CH3:21])[CH2:20][NH:8][CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86596346HCID 86596346, compound

Product 1

HCID 86596345HCID 86596345, compoundYield 95.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 0.20 g (0.59 mmol) (4R,9aR)-6-chloro-4,7-dimethyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester in 2 mL dichloromethane was added 0.91 mL (1.35 g, 11.8 mmol) trifluoroacetic acid. After 30 min., all volatile components were removed at a rotary evaporator and the residue was purified by column chromatography on silica gel with dichloromethane:methanol:ammonia (19:1:0.1) as eluant to give the desired compound as a colourless oil (95.9%).

Workup

  1. customall volatile components were removed at a rotary evaporator
  2. customthe residue was purified by column chromatography on silica gel with dichloromethane:methanol:ammonia (19:1:0.1) as eluant

Sources & evidence

ORD record
ord-c688b6a28e7d4cdda397e2d9cc7195e4
Source dataset
uspto-grants-2007_04
Patent number
US07208494B2

Reaction notes

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