HCID 69357759, compound → HCID 69359065, compound

HRID 1272162Notes

Reaction equation

HRID 1272162 reaction equation
C(OC([N:8]1[CH2:20][C@@H:19]([CH3:21])[N:18]2[C@H:10]([CH2:11][C:12]3[C:17]2=[N:16][CH:15]=[C:14]([F:22])[CH:13]=3)[CH2:9]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[NH3:8].[F:22][C:14]1[CH:13]=[C:12]2[C:17]([N:18]3[C@H:10]([CH2:11]2)[CH2:9][NH:8][CH2:20][C@H:19]3[CH3:21])=[N:16][CH:15]=1

Participants

4

Reactant 1

HCID 69357759HCID 69357759, compound

Product 2

HCID 222AmmoniaHCID 69359065HCID 69359065, compoundYield 150.5%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 0.138 g (4R,9aR)-7-fluoro-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester in 1.5 mL trifluoroacetic acid was kept at room temperature for 1 h. The solvent was evaporated and the residue was purified by chromatography on silica gel with dichloromethane:methanol:sat. ammonia (9:1:0.1) to yield 0.070 g (4R,9aR)-7-fluoro-4-methyl-1,2,3,4,9,9a-hexahydro-2,4a,5-triaza-fluorene as slightly yellow oil.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by chromatography on silica gel with dichloromethane

Sources & evidence

ORD record
ord-954ffeebf69c45239f7bbb71c3d8dde7
Source dataset
uspto-grants-2007_04
Patent number
US07208494B2

Reaction notes

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