反应详情

A mixture of 5-(2-fluoro-5-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride (Prep99, 300 mg, 1.16 mmol), and K2CO3 (241 mg, 1.7 mmol) in DMF (5 ml) was stirred for one hour at room temperature. 3-Bromo-1,1dimethoxy-propane (234 mg, 1.3 mmol) was added and stirring was continued for three days. Water was added and the product was extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated. The crude was purified by flash chromatography eluting with DCM-MeOH—NH4OH (95:5:0.5) to give 200 mg of the final compound as oil (53% yield).

1. stirringstirring
2. waitwas continued for three days
3. extractionthe product was extracted with ethyl acetate
4. dry with materialThe organic phase was dried (Na2SO4)
5. filtrationfiltered
6. customevaporated
7. customThe crude was purified by flash chromatography
8. washeluting with DCM-MeOH—NH4OH (95:5:0.5)