Pyrrolidine → 2-Amino-5-pyrrol-1-yl-1,3,4-thiadiazole

HRID 1272715Notes

Reaction equation

HRID 1272715 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:6][C:7]1[S:8][C:9](Cl)=[N:10][N:11]=1>C(O)C>[NH2:6][C:7]1[S:8][C:9]([N:1]2[CH:5]=[CH:4][CH:3]=[CH:2]2)=[N:10][N:11]=1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 3142355-Chloro-1,3,4-thiadiazol-2-amine

Product 1

HCID 184577892-Amino-5-pyrrol-1-yl-1,3,4-thiadiazole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

Pyrrolidine (200 μl) was added to a solution of 2-amino-5-chloro-1,3,4-thiadiazole (60 mg) in ethanol (2 ml) and the mixture heated in a sealed vial at 40° C. for 6 hours. The precipitate was filtered off and washed with a little methanol to give 2-amino-5-pyrrol-1-yl-1,3,4-thiadiazole.

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with a little methanol

Sources & evidence

ORD record
ord-92e5e25105d84f3d9a06d72b5f55d842
Source dataset
uspto-grants-2007_04
Patent number
US07208629B2

Reaction notes

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