Tert-Butylamine → HCID 131724922, compound

HRID 1273011Notes

Reaction equation

HRID 1273011 reaction equation
C([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][O:13]1)[N:7]=[C:6]2[C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21](O)=[O:22])#N.C1C=CC2N(O)N=[N:33][C:31]=2C=1.CCN=C=NCCCN(C)C.[C:48]([NH2:52])([CH3:51])([CH3:50])[CH3:49]>>[C:48]([NH:52][C:21]([C:20]1[CH:24]=[CH:25][CH:26]=[C:18]([C:6]2[C:5]3[C:9](=[CH:10][CH:11]=[CH:3][CH:4]=3)[N:8]([CH:12]3[CH2:17][CH2:16][CH:15]([C:31]#[N:33])[CH2:14][O:13]3)[N:7]=2)[CH:19]=1)=[O:22])([CH3:51])([CH3:50])[CH3:49]

Participants

5

Reactant 4

HCID 6385Tert-ButylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 22480305HCID 22480305, compound

Product 1

HCID 131724922HCID 131724922, compoundYield 77.8%

Procedure

Following Example 357, the reaction of 3-(5-cyano-1-perhydro-2H-pyran-2-yl-1H-indazol-3-yl)benzoic acid (0.8 g, 2.3 mmol), HOBT (1.16 g, 8.62 mmol), EDCI (1.64 g, 8.62 mmol) and tert-butylamine (0.73 mL, 0.5 g, 6.9 mmol) furnished 0.72 g (74% yield) of the title compound. ES-MS (m/z) 403 [M+H]+.

Sources & evidence

ORD record
ord-5c33b44526aa4b939e7e7fd51781dc80
Source dataset
uspto-grants-2007_04
Patent number
US07208513B2

Reaction notes

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