反应详情

A solution of methylamine in ethanol/ethylenedichloride (112.5 ml of 33% ethanolic methylamine in 0.8 liters of ethylene dichloride; 0.94 mole) was added over 51/2 hr at 70° to a stirred solution of 1,1-bismethylthio-2-nitroethene (99.0 g, 0.6 mole) in ethylene dichloride (1.5 liters). The solution was heated to boiling and 0.7 liters of solvent were distilled off. The cooled solution was washed with 2N hydrochloric acid (0.25 liters), then with brine (0.25 liters). The solvent was removed and the residue crystallised from isopropyl acetate (0.5 liters), treating the hot solution with charcoal (10.0 g). The product (35.0 g) formed yellow prisms, m.p. 114°.

1. temperatureThe solution was heated
2. distillation0.7 liters of solvent were distilled off
3. washThe cooled solution was washed with 2N hydrochloric acid (0.25 liters)
4. customThe solvent was removed
5. customthe residue crystallised from isopropyl acetate (0.5 liters)
6. additiontreating the hot solution with charcoal (10.0 g)