Indomethacin → HCID 178487182, compound

HRID 1273287Notes

Reaction equation

HRID 1273287 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.Nc1cc(-c2ccccc2)nn1-c1ccccc1>C1CCOC1.CN(C)C(=[O+]n1nnc2cccnc21)N(C)C.CN1CCOCC1.F[P-](F)(F)(F)(F)F>COc1ccc2c(c1)c(CC(=O)Nc1cc(-c3ccccc3)nn1-c1ccccc1)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 1999691,3-Diphenyl-1H-pyrazol-5-amine

Product 1

HCID 178487182HCID 178487182, compoundYield 6.35%

Reagents, catalysts & solvents 3

HCID 79724-MethylmorpholineReagentHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)ReagentHCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-fa35751be2e64544892f64173e0e73b0
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

Loading…