Indomethacin → HCID 178487184, compound

HRID 1273408Notes

Reaction equation

HRID 1273408 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.Cc1cc(C)c(N)c(Br)c1>C1CCOC1.CCN(C(C)C)C(C)C.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>COc1ccc2c(c1)c(CC(=O)Nc1c(C)cc(C)cc1Br)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 1705792-Bromo-4,6-dimethylaniline

Product 1

HCID 178487184HCID 178487184, compoundYield 6.78%

Reagents, catalysts & solvents 3

HCID 81531DiisopropylethylamineReagentHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideReagentHCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-12bf9cee254d4f909e85da8ce80ff27c
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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