Indomethacin → HCID 178487189, compound

HRID 1273630Notes

Reaction equation

HRID 1273630 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.Cc1cc([N+](=O)[O-])ccc1N>CN(C)C=O.Cc1cccc(C)n1.O=P(Cl)(c1ccccc1)c1ccccc1>COc1ccc2c(c1)c(CC(=O)Nc1ccc([N+](=O)[O-])cc1C)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 74412-Methyl-4-nitroaniline

Product 1

HCID 178487189HCID 178487189, compoundYield 1.62%

Reagents, catalysts & solvents 3

HCID 79372,6-LutidineReagentHCID 73910Diphenylphosphinic chlorideReagentHCID 6228DimethylformamideSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-cb9477bae5064b6190d72cb0a343cbf1
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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