Indomethacin → HCID 178487186, compound

HRID 1273887Notes

Reaction equation

HRID 1273887 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.N=c1ccc(Cl)n[nH]1>C1CCOC1.CN1CCOCC1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>COc1ccc2c(c1)c(CC(=O)Nc1ccc(Cl)nn1)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 178507598HCID 178507598, compound

Product 1

HCID 178487186HCID 178487186, compoundYield 19.57%

Reagents, catalysts & solvents 3

HCID 79724-MethylmorpholineReagentHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideReagentHCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-f8dcf6aa99164a4a8a514f8e7d2f9e22
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

Loading…