Indomethacin → HCID 178487186, compound

HRID 1273923Notes

Reaction equation

HRID 1273923 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.N=c1ccc(Cl)n[nH]1>C1CCOC1.CCOC(=O)C(C#N)=N[O+]=C(N(C)C)N(C)C.CN1CCOCC1.F[P-](F)(F)(F)(F)F>COc1ccc2c(c1)c(CC(=O)Nc1ccc(Cl)nn1)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 178507598HCID 178507598, compound

Product 1

HCID 178487186HCID 178487186, compoundYield 30.04%

Reagents, catalysts & solvents 3

HCID 79724-MethylmorpholineReagentHCID 573489556-Cyano-N,N,2-trimethyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-iminium hexafluorophosphateReagentHCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-e69b956e22eb48519576d7ec380089e4
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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