Indomethacin → HCID 178498032, compound

HRID 1273990Notes

Reaction equation

HRID 1273990 reaction equation
COC(=O)c1ccc(Cl)cc1N.COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1>CN(C)C=O.Cc1cccc(C)n1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>COC(=O)c1cc(Cl)ccc1NC(=O)Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c2ccc(OC)cc12

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 80001Methyl 4-chloroanthranilate

Product 1

HCID 178498032HCID 178498032, compoundYield 4.21%

Reagents, catalysts & solvents 3

HCID 79372,6-LutidineReagentHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideReagentHCID 6228DimethylformamideSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-e73482076dd24c3da769ac887a8eb4f7
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

Loading…