Sodium Hydroxide → 2-(Propylthio)pyrimidine-4,6-diol

HRID 1274196Notes

Reaction equation

HRID 1274196 reaction equation
[CH2:1](I)[CH2:2][CH3:3].[OH:5][C:6]1[CH:11]=[C:10]([OH:12])[N:9]=[C:8]([SH:13])[N:7]=1.[OH-].[Na+]>O>[OH:5][C:6]1[CH:11]=[C:10]([OH:12])[N:9]=[C:8]([S:13][CH2:1][CH2:2][CH3:3])[N:7]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 336431-IodopropaneHCID 178516656HCID 178516656, compound

Product 1

HCID 1784608102-(Propylthio)pyrimidine-4,6-diol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Propyl iodide (136 ml) was added to a suspension of 4,6-dihydroxy-2-mercaptopyrimidine (200 g) in water (800 ml), containing sodium hydroxide (55.6 g). The reaction mixture was stirred for 2 weeks then concentrated to half volume, 2N hydrochloric acid added and the product isolated by filtration (167 g).

Workup

  1. concentrationthen concentrated to half volume, 2N hydrochloric acid
  2. additionadded
  3. customthe product isolated by filtration (167 g)

Sources & evidence

ORD record
ord-e0112a49ba2b42f480dbd187de6f84ea
Source dataset
uspto-grants-2000_12
Patent number
US06156756

Reaction notes

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