Methyl iodide → HCID 10990514, compound

HRID 1274242Notes

Reaction equation

HRID 1274242 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH2:10][C:9]2=[O:13])[CH:5]=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([OH:22])=[O:21])=[CH:16][CH:15]=1.IC.[C:25](=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH2:10][C:9]2=[O:13])[CH:5]=[CH:4][C:3]=1[C:14]1[CH:15]=[CH:16][C:17]([C:20]([O:22][CH3:25])=[O:21])=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 230052992'-Methyl-4'-(2-oxopyrrolidin-1-yl)[1,1'-biphenyl]-4-carboxylic acid

Product 1

HCID 10990514HCID 10990514, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared from 2'-methyl-4'-(2-oxopyrrolidin-1-yl)biphenyl-4-carboxylic acid (D13) by stirring a DMF solution together with iodomethane and potassium carbonate for 3 hours, followed by dilution with water and extraction into ethyl acetate.

Workup

  1. extractionfollowed by dilution with water and extraction into ethyl acetate

Sources & evidence

ORD record
ord-2ad7524bf14b4b6980259c70d067c651
Source dataset
uspto-grants-2000_12
Patent number
US06156783

Reaction notes

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