Tert-Butyl nitrite → HCID 9887618, compound

HRID 1274362Notes

Reaction equation

HRID 1274362 reaction equation
N[C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[C:21]1[CH:25]=[CH:24][O:23][C:22]=1[Cl:26].N(OC(C)(C)C)=O>O1CCCC1>[Cl:26][C:22]1[O:23][CH:24]=[CH:25][C:21]=1[C:3]1[C:4]([C:19]#[N:20])=[N:5][N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:15])[F:16])=[CH:9][C:8]=2[Cl:18])[CH:2]=1

Participants

4

Reactant 2

HCID 10906Tert-Butyl nitriteHCID 221209155-Amino-4-(2-chlorofuran-3-yl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

Product 1

HCID 9887618HCID 9887618, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
65 °C

Procedure

To a solution of 5-amino-4-(2-chlorofuran-3-yl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (0.204 g) in tetrahydrofuran (3 ml) was added t-butyl nitrite (171.8 μl). The mixture was heated to 65° C. for 1 hour, then cooled and evaporated. The residue was purified by column chromatography on silica gel (10 g) eluted with hexane containing increasing amounts of dichloromethane (up to 100%). Combination and evaporation of appropriate fraction gave the title compound as a white solid, m.p. 125° C.

Workup

  1. temperaturecooled
  2. customevaporated
  3. customThe residue was purified by column chromatography on silica gel (10 g)
  4. washeluted with hexane containing
  5. temperatureincreasing amounts of dichloromethane (up to 100%)
  6. customCombination and evaporation of appropriate fraction

Sources & evidence

ORD record
ord-49409b4237ab473c9117c039ac4a6c9e
Source dataset
uspto-grants-2000_12
Patent number
US06156782

Reaction notes

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