反应详情

To a solution of 4-chloro-3-nitrophenol (5.00 g, 29 mmol) in acetone (50 ml) were added ethyl iodide (4.95 g, 32 mmol) and potassium carbonate (4.37 g, 32 mmol), followed by stirring at room temperature for 20 hours. After filtration of the insoluble matter, the filtrate was subjected to evaporation under reduced pressure to remove the solvent, and the residue was purified by silica gel column chromatography (eluent; chloroform) to give 4-ethoxy-1-chloro-2-nitrobenzene (5.71 g).

1. filtrationAfter filtration of the insoluble matter
2. customthe filtrate was subjected to evaporation under reduced pressure
3. customto remove the solvent
4. customthe residue was purified by silica gel column chromatography (eluent; chloroform)