反应详情

A mixture of 5-pyrazin-2-yl-1H-pyrimidine-2,4-dione hydrochloride (Prep125, 2.19 mmol), and K2CO3 (302 mg, 2.19 mmol) in DMF (20 ml) was stirred 30 minutes at room temperature. 90% 3-Bromo-1,1dimethoxy-propane (365 μl, 2.41 mmol) was added in two portions during 2 days. Water was added and the mixture was extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated. The crude was purified by flash chromatography eluting with DCM-MeOH—NH4OH (98-2-0.2) to give 221 mg of the title compound (35% yield).

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialThe organic phase was dried (Na2SO4)
3. filtrationfiltered
4. customevaporated
5. customThe crude was purified by flash chromatography
6. washeluting with DCM-MeOH—NH4OH (98-2-0.2)