Hydrochloric Acid → HCID 21249820, compound

HRID 1274834Notes

Reaction equation

HRID 1274834 reaction equation
COC(=O)C1C=CC=CN=1.[CH3:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([C:30]([OH:32])=[O:31])=[N:17][C:18]=1[O:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=1.[OH-].[Na+].Cl>C(O)C>[CH3:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([C:30]([OH:32])=[O:31])=[N:17][C:18]=1[O:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:28])([F:29])[F:27])[CH:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 70268678HCID 70268678, compound

Product 1

HCID 21249820HCID 21249820, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

5-methoxy-6-[3-(trifluoromethyl)phenoxy] picolinic acid picolinic acid methyl ester (0.7 g, 0.0021 mol) was dissolved in 2.8 ml of ethyl alcohol. One milliliter of an aqueous solution of sodium hydroxide (0.102 g, 0.0021×1.2 mol) was added to the obtained solution. The resultant mixture was heated and stirred at 70° C. for 1.5 hours. After cooling, the obtained reaction solution was mixed with 2 ml of concentrated hydrochloric acid, thereby precipitating solids. The precipitated solids were filtered out from the solution, washed with water and then dried.

Workup

  1. temperatureAfter cooling
  2. customthe obtained reaction solution
  3. customprecipitating solids
  4. filtrationThe precipitated solids were filtered out from the solution
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-84b679b2d76b4c27ac2d97093fede183
Source dataset
uspto-grants-2000_12
Patent number
US06159901

Reaction notes

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