反应详情

A solution of 5.0 g of 5-chloro-6-chloromethyluracil, 6.14 g of 2-iminopyrrolidine and 5.24 g of sodium ethoxide in N,N-dimethylformamide (50 ml) was stirred at room temperature for 14 hours. A crystallized matter was collected by filtration and then suspended in 30 ml of water. After the suspension was neutralized with acetic acid and then washed, an insoluble matter was collected by filtration and then dissolved in 60 ml of 1 N hydrochloric acid. Activated carbon was added to the resultant solution, followed by filtration. The filtrate was concentrated under reduced pressure, and the residue so obtained was washed with ethanol and collected with filtration, whereby 2.68 g of the title compound were obtained (yield: 38%).

1. filtrationA crystallized matter was collected by filtration
2. washwashed
3. filtrationan insoluble matter was collected by filtration
4. dissolutiondissolved in 60 ml of 1 N hydrochloric acid
5. additionActivated carbon was added to the resultant solution
6. filtrationfollowed by filtration
7. concentrationThe filtrate was concentrated under reduced pressure
8. customthe residue so obtained
9. washwas washed with ethanol
10. filtrationcollected with filtration