Dichloromethane → HCID 53730086, compound

HRID 1274899Notes

Reaction equation

HRID 1274899 reaction equation
[F:1][C:2]1([C:11]2[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[CH:13][CH:12]=2)[CH2:4][CH:3]1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[Cl:20]CCl.C(Cl)(=O)C(Cl)=O>CN(C)C=O>[F:1][C:2]1([C:11]2[CH:19]=[CH:18][C:14]([C:15]([Cl:20])=[O:16])=[CH:13][CH:12]=2)[CH2:4][CH:3]1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 15340055HCID 15340055, compound2×

Product 1

HCID 53730086HCID 53730086, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
0 °C

Procedure

0.35 g of 4-(1-fluoro 2-phenyl cyclopropyl) benzoic acid (mixture (B)), obtained according to Preparation 1, and 20 cm3 of dichloromethane are mixed together under an inert gas atmosphere, the mixture is cooled down to 0° C., 0.207 g of commercial oxalyl chloride and 0.01 cm3 of dimethylformamide are added, the whole is agitated for 3 hours at 20-25° C. and brought to dryness in order to collect the acid chloride.

Workup

  1. additionare mixed together under an inert gas atmosphere
  2. customto collect the acid chloride

Sources & evidence

ORD record
ord-2897ed35655b4f0f9189d8d4f97245d8
Source dataset
uspto-grants-2000_12
Patent number
US06159973

Reaction notes

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