Potassium Carbonate → HCID 22118898, compound

HRID 1275010Notes

Reaction equation

HRID 1275010 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([Br:20])=[C:10]([N:13]3[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]3)[CH:11]=2)[CH:6]=[CH:5]1)(=O)C.C([O-])([O-])=O.[K+].[K+]>Br>[Br:20][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][C:10]=1[N:13]1[CH2:14][CH2:15][N:16]([CH3:19])[CH2:17][CH2:18]1)[NH:4][CH2:5][CH2:6]2

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22118929HCID 22118929, compound

Product 1

HCID 22118898HCID 22118898, compoundYield 58.1%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A solution of 1-acetyl-5-bromo-6-(4-methylpiperazin-1-yl)-1H-indole (D12, 0.60 g, 1.8 mmole) in 2M hydrobromic acid (50 ml) was stirred at room temperature for 5 days, then basified by addition of solid K2CO3 and extracted with DCM. The extract was dried (Na2SO4) and concentrated in vacuo to afford the title compound as a brown solid (0.31 g, 58%).

Workup

  1. extractionextracted with DCM
  2. dry with materialThe extract was dried (Na2SO4)
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b9d66c6dbc1b456eb63e920b5a2077fa
Source dataset
uspto-grants-2000_12
Patent number
US06159979

Reaction notes

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